Position of central venous catheters in children.

The ideal frequency of nebulized 3% saline is unclear, though most studies have found multiple daily doses for several days to be effective as opposed to repeated inhalations over a short period [4]. This possibly can serve as a major advantage over inhaled epinephrine where repeated use can be limited by tachycardia and/or rebound mucosal edema. Ralston, et al. [8] in their study found a low rate of adverse events when hypertonic saline was used without adjunctive bronchodilators. Such reports; however, are far and few as most studies on hypertonic saline in bronchiolitis including the current one [5] have combined it with some bronchodilator to counter the theoretical risk of precipitating bronchospasm.